Rodent pharmacokinetics (in life) vivarium studies are conducted in-house on different strains of mice and rats, in accordance with the following certifications, compliances and quality systems:
Ninety SOPs have been established for the regular functioning of the vivarium and for the various studies being conducted.
In-house, experienced scientists conduct cannulations, ensuring minimal stress to the animals, with cost-effectiveness. Sampling can be done through portal/ tail/ saphenous/ submandibular veins. Wherever possible, we employ the principle of 3Rs. Serial sampling is preferred, to reduce the number of animals and generate quality, robust data.
Large Animals: Canine PK studies are conducted with an external collaborator having a colony of more than 400 animals at a time.
| Study Type | TAT (Days) | Compound Requirement (mg) |
| Rat PK | 5 | 25 |
| Mouse PK: serial sampling | 5 | 10 |
| Mouse PK: parallel sampling | 5 | 20 |
| Rat Blood Brain Barrier | 5 | 15 |
| Mouse Blood Brain Barrier | 5 | 15 |
| Cassette dosing | 5 | 25 in rats |
Novel fibrosis assays for large and small molecule therapeutics including EMT, FMT and precision-cut lung slices assay.
Different animal protocols, optimized planning, and experimental design to accelerate research programs.
We offer a combination of in vitro and in vivo toxicology assays coupled with GLP bioanalysis to help de-risk drug candidates and enable critical and timely go/no-go pipeline decisions.
