Brochure

Peptide Technology Platform

Chemistry Expertise

Linear, branched, cyclic and stapled peptides
40-50 AA, mg to gm, singleton or peptide libraries
Liquid, solid-liquid, hybrid, TAG-assisted, native chemical ligation
C- & N-terminal, cyclization, backbone modifications and conjugation reactions
Purification and characterization

Biology Expertise

Peptide mapping/ fingerprinting
Plasma protein binding using Rapid Equilibrium Dialysis or Ultrafiltration
Stability in buffer, simulated gastric fluids, liver, kidney, intestinal S9, hepatocytes or plasma
Half-life, metabolite identification and profiling
Pharmacokinetics and Quantitative bioanalysis: rat, mouse, dog, rabbit
Mass/QTof spectrometry analysis

Track Record of Success

Library development: linear/cyclic peptides, 2-10 mg, up to 50 mers, >95% purity
Successful synthesis of challenging peptide moities
- Hydrophobic peptides with disruptors (dmb, hmb protected amino acids / pseudoprolines, chaotropic agents)
- Cyclic peptides (S-S bridging, cyclization, stapling, RCM)
- Process optimization to multi-gm scale
- Long chain peptides and foldings (>100 mers, NCL/KAHA)

World Class Infrastructure

Silicycle mini block work station
Automated synthesizer with online UV
Up to 5 L reactors for scale up
Lyophilization at scale

Analytical Capabilities

Peptide characterization by UV, LCMS, HRMS and NMR
Purification by RP Preparative HPLC (2000 to 40000 Da)
Quality control of all custom peptides and peptide libraries