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Intox Safety Assessment

Industries we serve

Pharma/ Biotech
Medical Devices
Plant Protection
Industrial Chemicals
Nutraceuticals

Regulatory Compliances

Test systems and routes of administration

Test Species

Rats, mice, guinea pigs, rabbits, hamsters
Dogs and Non-Human Primates, available through our
collaborating test facilities

Routes of Administration

Oral (gavage & dietary), dermal, inhalation, parenteral (IV/SC/IM/ID)
Other – Intranasal, ocular, intra-vitreal, otic, intra-articular;
Implantation

Bioanalytical / Bioassay Solutions

Single/Repeated Dose Pharmacokinetics
Toxicokinetics
Immunogenicity (ADA)
Immunotoxicology
Biomarkers
Acute Phase Proteins
Biodistribution/Persistence

Bioanalytical Techniques

LC–MS (liquid chromatography–mass spectrometry)
GC–MS (gas chromatography–mass spectrometry)
HPLC (high performance liquid chromatography)
Ligand binding assay (LBA) Platforms- ELISA and Meso Scale
Discovery (MSD)

Studies offered

Mutagenicity:

In-vitro / in-vivo studies
Gene mutation – Bacterial (Ames test); mammalian cells
Chromosome Aberration; Micronucleus Test

Acute Toxicity:

Acute oral, dermal, inhalation toxicity;
Acute dermal & eye irritation/ corrosion; Mucous membrane irritation;
Skin sensitization – Buehler, GPMT, LLNA

Subchronic / Chronic Toxicity / Carcinogenicity

7-day (DRF), 14-day, 28-day, 90-day, 180-day and
12-month repeat dose studies
18-month/24-month carcinogenicity bioassays
Implantation studies on medical devices

Reproductive Toxicity

Fertility, Developmental toxicity, One/Multi-generation
studies