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Formulation Development Solutions

Pre-Formulation Development

Physical form selection
  • Crystallisation
  • Salt screening
  • Co-crystal screening
  • Polymorph screening
Oral delivery
  • Suspension
  • Solution
  • Microemulsion
  • Solid dispersion
  • Nanosuspension
Parenteral delivery
  • Solution
  • Suspension
  • Liposomes
  • Microparticles
  • In-situ gels
Topical delivery
  • Lotion
  • Gel
  • Cream
  • Ointment
Nasal delivery
  • Solution
  • Suspension
  • Emulsion
  • Dry powders
Preclinical studies
Support
  • Efficacy studies
  • PK studies
  • Exploratory tox studies
  • GLP tox studies

Formulation Development and Manufacturing

Tablets
  • Immediate Release
  • Sustained Release
  • Mini
  • Bilayer
  • Delayed Release
  • Colon delivery
  • Oral films
Liquids
  • Suspension
  • Solution
  • Emulsion
Parenterals
  • Solution
  • Suspension
  • Lyophilised
  • Ophthalmic
  • Nebulised
  • Vial/Ampule/
  • Pre-filled Syringe

Capsules
  • Powder
  • Pellets
  • Liquids
Semisolids
  • Gel
  • Cream
  • Ointment
  • Lotion
Processes/
Technologies
  • Wet Granulation
  • Roller Compaction
  • Micronisation
  • Nanomilling
  • Spray Drying
  • Fluid Bed Coating
  • Tabletting
  • Capsule Filling
  • Film coating
  • Packaging

 

Novel Drug Delivery System
Development (Oral)

Solid Dispersion

For poorly soluble compounds to increase dissolution rate and saturation solubility amorphous drug within a polymer

Microemulsion

Avoid influence of solid form. Increase solubility in GI tract. Compound is completely solubilized

Nanosuspension

For poorly soluble compounds to increase dissolution rate and saturation solubility crystals in nano size range

Novel Drug Delivery System
Development (Parenteral)

Parentera

Targeted drug delivery system

Microemulsion

Long-acting Injectable microspheres using biodegradable polymers

In Situ Gels

Controlled release of drug using thermo-sensitive polymer gels